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Analyst Price Targets — SYRE

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DateAnalystFirmTargetPrice @ PostSourceHeadline
December 17, 2025 9:08 pmMizuho Securities$53.00$33.06TheFly Spyre Therapeutics initiated with an Outperform at Mizuho
September 26, 2025 8:34 amDeutsche Bank$43.00$16.24TheFly Spyre Therapeutics initiated with a Buy at Deutsche Bank
November 12, 2024 5:50 pmAlex ThompsonStifel Nicolaus$71.00$35.52StreetInsider Spyre (SYRE) PT Raised to $71 at Stifel
October 17, 2024 6:50 amColleen KusyRobert W. Baird$50.00$32.37StreetInsider Baird Reiterates Outperform Rating on Spyre (SYRE)
October 15, 2024 6:18 amYanan ZhuWells Fargo$40.00$30.66StreetInsider Wells Fargo Reiterates Overweight Rating on Spyre (SYRE)
May 10, 2024 7:25 amJulian HarrisonBTIG$40.00$35.19TheFly Spyre Therapeutics price target raised to $40 from $32 at BTIG

Latest News for SYRE

Spyre Therapeutics to Participate in Upcoming March Investor Conferences

WALTHAM, Mass., Feb. 24, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE), a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (“IBD”) and rheumatic diseases, today announced that management will participate in the following upcoming investor conferences:

GlobeNewsWire • Feb 24, 2026
Spyre Therapeutics Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Corporate Update

On track for 6 proof-of-concept readouts in 2026 across the SKYLINE and SKYWAY Phase 2 trials  Part A readouts from SKYLINE platform trial in ulcerative colitis ("UC") expected to begin in the second quarter, with enrollment continuing ahead of schedule Enrollment on track in Phase 2 SKYWAY basket trial evaluating TL1A inhibition in rheumatoid arthritis ("RA"), psoriatic arthritis ("PsA"), and axial…

GlobeNewsWire • Feb 19, 2026
Spyre Therapeutics Announces Grants of Inducement Awards

WALTHAM, Mass., Feb. 06, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease and rheumatic diseases, today announced that Spyre's independent Compensation Committee of the Board of Directors approved the grant of…

GlobeNewsWire • Feb 6, 2026
Short Interest in Spyre Therapeutics, Inc. (NASDAQ:SYRE) Drops By 13.5%

Spyre Therapeutics, Inc. (NASDAQ: SYRE - Get Free Report) was the target of a large drop in short interest in the month of January. As of January 15th, there was short interest totaling 10,069,741 shares, a drop of 13.5% from the December 31st total of 11,636,998 shares. Approximately 13.8% of the company's shares are short sold.

Defense World • Feb 5, 2026

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