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Analyst Price Targets — SYRE

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DateAnalystFirmTargetPrice @ PostSourceHeadline
April 14, 2026 11:31 amRobert W. Baird$90.00$63.27TheFly Spyre Therapeutics price target raised to $90 from $65 at Baird
April 14, 2026 10:29 amWells Fargo$90.00$63.27TheFly Spyre Therapeutics price target raised to $90 from $50 at Wells Fargo
April 14, 2026 8:35 amDeutsche Bank$88.00$63.27TheFly Spyre Therapeutics price target raised to $88 from $55 at Deutsche Bank
April 13, 2026 8:07 pmRaymond James$80.00$63.27TheFly Spyre Therapeutics initiated with a Strong Buy at Raymond James
April 13, 2026 6:51 pmDavid NierengartenWedbush$80.00$63.27TheFly Spyre Therapeutics price target raised to $80 from $65 at Wedbush
April 13, 2026 6:42 pmLeerink Partners$106.00$63.27TheFly Spyre Therapeutics price target raised to $106 from $49 at Leerink
April 13, 2026 6:23 pmJulian HarrisonBTIG$98.00$63.26TheFly Spyre Therapeutics price target raised to $98 from $70 at BTIG
April 13, 2026 4:44 pmJefferies$85.00$64.78TheFly Spyre Therapeutics price target raised to $85 from $47 at Jefferies
March 16, 2026 3:33 pmWilliam Blair$49.00$43.70StreetInsider Leerink Partners Reiterates Outperform Rating on Spyre (SYRE): 'today's update reflects SYRE's strong clinical execution'
December 17, 2025 9:08 pmMizuho Securities$53.00$33.06TheFly Spyre Therapeutics initiated with an Outperform at Mizuho

Latest News for SYRE

Spyre Therapeutics, Inc. Announces Closing of Public Offering and Full Exercise of the Underwriters' Option to Purchase Additional Shares for Gross Proceeds of $463.5 Million

WALTHAM, Mass., April 16, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (“Spyre” or the “Company”) (Nasdaq: SYRE), a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases, today announced the closing of its previously announced underwritten public offering of 7,475,000 shares of…

GlobeNewsWire • Apr 16, 2026
Spyre Therapeutics (NASDAQ:SYRE) Shares Gap Up Following Analyst Upgrade

Spyre Therapeutics, Inc. (NASDAQ: SYRE - Get Free Report)'s share price gapped up before the market opened on Tuesday after Robert W. Baird raised their price target on the stock from $65.00 to $90.00. The stock had previously closed at $63.27, but opened at $67.68. Robert W. Baird currently has an outperform rating on the stock.

Defense World • Apr 15, 2026
Spyre Therapeutics Announces Pricing of Upsized $403.0 Million Public Offering of Common Stock

WALTHAM, Mass., April 14, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (“Spyre” or the “Company”) (Nasdaq: SYRE), a clinical-stage biotechnology company advancing best-in-class antibody engineering, dose optimization, and rational therapeutic combinations for the treatment of Inflammatory Bowel Disease (“IBD”) and other immune-mediated diseases, today announced the pricing of its previously announced…

GlobeNewsWire • Apr 14, 2026
Spyre Therapeutics: Strong SPY001 Data Set Up A Catalyst-Rich 2026

Spyre Therapeutics delivered strong Phase 2 data for SPY001, showing rapid, deep efficacy and a clean safety profile in ulcerative colitis. SPY001 achieved a 9.2-point RHI reduction, 40% clinical remission, and 51% endoscopic improvement at 12 weeks, suggesting best-in-class potential. Valuation reflects high expectations for SPY001 and combination regimens, with a $3-4B enterprise value and significant premium for…

Seeking Alpha • Apr 14, 2026
Spyre Therapeutics Announces Proposed Public Offering of its Common Stock

WALTHAM, Mass., April 13, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (“Spyre” or the “Company”) (Nasdaq: SYRE), a clinical-stage biotechnology company advancing best-in-class antibody engineering, dose optimization, and rational therapeutic combinations for the treatment of Inflammatory Bowel Disease (“IBD”) and other immune-mediated diseases, today announced that it has commenced an underwritten public…

GlobeNewsWire • Apr 13, 2026

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